Connect with us

Health

Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis – News-Medical.net

Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA),…

Published

on

Article feature image

Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA), psoriasis andmultiple sclerosis(MS).
The authors designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents. 2-Acrylamidobenzoic acid analog11was identified as the lead compound for structure-activity relationship (SAR) studies.
The replacement of thephenyl group with naphthylmoieties…

Click here to view the original article.

Continue Reading
Advertisement

You might also like ...

Article feature image
Broadly neutralizing antibodies show promise in preventing tick-borne encephalitis in mice – News-Medical.Net
Article feature image
Toddler’s gruelling 694-day stint in hospital ends: ‘I thought some days it would never happen’ – 9Honey